programmed death-1 gene polymorphism (pd-1.5 c/t) is associated with gastric cancer

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : this study aimed to determine the association between pd-1.5c/t (rs2227981, +7785) and the risk of gastric cancer (gc) in an iranian population. background : gastric cancer is the fourth most common cancer in the world. the programmed death 1 (pd-1) is a member of the cd28 super family. pd-1 is a negative regulator of t-cell effector mechanisms which decrease immune responses against cancer. patients and methods : we conducted case- control study to investigate the association of pd-1.5 c/t polymorphism in 122 gc patients and 166 control individuals. dna was extracted from blood specimens. genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) assay. results : the frequency of cc, ct and tt genotypes was 53.6%, 42.2% and 4.2% in control group and 41%, 54.1% and 4.9% in gastric cancer patients respectively. cc genotype was more frequent in control individuals than in patients but we found no statically significant association. the frequencies of pd-1.5ct genotypes were significantly higher in gc patient compared with control individuals (or= 1.77, 95% ci= 1.077-2.931; p =0.026). allele distribution was similar in patients and healthy individuals (p=0.061).frequency of c and t alleles was 74.7%, 25.3% in control individuals and 68.03% and 31.97% in gastric cancer patients respectively. conclusion : these results suggest that pd-1.5 c/t polymorphism may affect the gc risk and prognosis in an iranian population.